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These highlights do not include all the information needed to use VIAGRA safely and effectively. VIAGRA® (sildenafil citrate) tablets, for oral use Initial U. Approval: 1998For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity. The maximum recommended dosing frequency is once per day. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. VIAGRA was shown to potentiate the hypotensive effects of nitrates and its administration in patients who use nitric oxide donors such as organic nitrates or organic nitrites in any form is therefore contraindicated [The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by 11-fold [Consider a starting dose of 25 mg in patients treated with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 3 fold [VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR25, VGR50 or VGR100 on the other to indicate the dosage strengths.], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated. Viagra er et lægemiddel, oprettet for mere end 15 år siden af det Amerikanske selskab Pfizer. Dens effektivitet er bekræftet af millioner af patienter verden over. Komponent, der Viagra på grund af dens effektivitet er sildenafil citrat er ansvarlige for den korrekte koncentrationen og aktiviteten af enzymer, der er ansvarlige for processen med erektion. Under seksuel ophidselse hule organer af penis frigive nitrogenoxid, hvilket forårsager en stigning i koncentrationen af cyklisk monofosforanu guanozyny (c GMP), som igen er ansvarlige for, afslappende glatte muskler i penis og bringe blod. Til forsvinden af erektion er resultatet af en indsats af enzymet phosphodiesterase type 5 (PDE 5), som forårsager nedbrydning af (c GMP). Den mest almindelige årsag til seksuelle problemer er for høj en koncentration af enzymet PDE 5. Sildenafil citrate er en selektiv hæmmer af enzymet phosphodiesterase type 5, som resulterer i langsommere nedbrydning af den cykliske monofosforany guanozyny.

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VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs fixed dose, titration, parallel, crossover. When using Viagra® sildenafil citrate for erectile dysfunction, the maximum amount a man should take each day is 100 mg. Viagra tablets are

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